Abstract
ABSTRACT
Aim: Metabolic syndrome, characterized by a cluster of conditions including central obesity, dyslipidemia, hypertension, and insulin resistance. Gastroesophageal reflux disease is a chronic condition in which stomach contents regurgitate into the esophagus. The association between metabolic syndrome and gastroesophageal reflux disease has garnered considerable attention.
Methods: Our study's case group consists of patients diagnosed with gastroesophageal reflux disease who have not used proton pump inhibitors. The control group, on the other hand, comprises patients who visited the gastroenterology outpatient clinic. Metabolic syndrome criteria were investigated in the participants. This study is retrospective in nature. For comparisons, the simple t-test was employed. Categorical data were analyzed using the Chi-square test. Continuous variables that did not conform to a normal distribution were analyzed using One-Way ANOVA and the Kruskal-Wallis tests.
Results: When comparing the BMI, waist circumference, and laboratory parameters of both groups, it was determined that the BMI and waist circumference values were significantly higher in the gastroesophageal reflux disease group compared to the control group (p=0.04 and p<0.01, respectively). Conversely, the levels of total cholesterol and triglycerides were significantly higher in the control group (both with p=0.01).
Conclusion: In conclusion, our study substantiates the significant association between metabolic syndrome, and gastroesophageal reflux disease highlighting the need for heightened awareness and integrated management strategies in affected individuals.

Key words: Key Words: Metabolic Syndrome, Gastroesophageal Reflux Disease, Central Obesity, Insulin Resistance, Pro-Inflammatory State.