Abstract
Orally disintegrating tablets (ODTs) are a new formulation that dissolves in saliva within seconds, and there is no need to drink water. Due to its many benefits, this dosage form is an effective way to administer active pharmacological substances, especially for pediatric, geriatric, psychiatric, paralyzed, and bedridden patients. ODTs have been shown to have superior patient compatibility and drug solubility in numerous studies that have compared this tablet form with conventional forms in vitro and in vivo. There are many substances used to achieve enhanced characteristics, including super disintegrants such as croscarmellose sodium and crospovidone to achieve rapid disintegration and dissolution, and selection of appropriate diluent, binder, sweetening agents, flavoring materials, and lubricant are required to make tablets dissolve quickly. This dosage type can be prepared in several techniques, including direct compression, sublimation, freeze-drying, lyophilization, spray drying, molding, Process of cotton candy, Massextrusion, phase extrusion, and Melt Granulation. Formulation and selection of appropriate excipients are discussed, and ODTs' preparation techniques are illustrated in this review. Laboratory evaluation and quality control measures, including precompression (micromeritics parameters) to adjust formulation and obtain the optimized formulations to be produced and scale up and post-compression parameters for ODTs, are also discussed in this review.

Key words: ODTs, formulation, pre-compression, post-compression, superdisintegrants