Hepatoprotective Effects of Dayak Onion (Eleutherine palmifolia) Extract on SGOT and SGPT Enzyme Activity in Mice (Mus musculus) Following Chronic Dose Administration of Monosodium Glutamate

Aldin Akbar Rahmatullah

doi:10.5455/JELM.20240704123811

Abstract
This study aimed to explore the liver-protecting properties of Dayak onion (Eleutherine palmifolia) extract in mice exposed to chronic doses of monosodium glutamate (MSG). The research involved 25 male mice, each about 11 weeks old and weighing around 20 grams. These mice were divided into five groups for different treatments. The control group (C-) received only a harmless substance, while the positive control group (C+) was given MSG at 4 mg per gram of body weight. The three treatment groups (T1, T2, and T3) received the same amount of MSG along with varying doses of Dayak onion extract: 30, 60, and 120 mg per kilogram of body weight, respectively. The experiment ran for 52 days. On the 53rd day, the researchers humanely euthanized the mice and collected blood samples directly from their hearts. This blood was used to measure the activity of two important liver enzymes: SGOT and SGPT. The results showed a significant difference in enzyme activity between the MSG-only group and the control group. Interestingly, in the groups treated with Dayak onion extract, the enzyme activity decreased as the extract dose increased. This suggests that the extract was counteracting the harmful effects of MSG on the liver. The researchers concluded that Dayak onion extract demonstrated protective effects on the liver in mice exposed to chronic doses of MSG. The most effective dose of Dayak onion extract was found to be 120 mg per kilogram of body weight. This study provides valuable insights into the potential of Dayak onion extract as a natural remedy for liver damage caused by MSG consumption, opening avenues for further research in this area.

Key words: Dayak Onion Extract, Monosodium glutamat, SGOT, SGPT, Hepatoprotector