Livolin Forte's Modulatory Effect on Haematological Parameters Caused by Sub-chronic Lead Acetate Administration In Wistar Rats

Ezekiel Moses; Mohammed  Mamman; Mufta Shittu

doi:10.5455/JELM.20241221092423

Abstract
ABSTRACT

Aim: This study evaluated the pretreatment and post-treatment effects of Livolin Forte® (LF) on haematological changes caused by sub-chronic lead acetate administration in male Wistar rats.
Methods: Thirty-six male rats weighing were divided into six groups. Group I received distilled water, Group II received propylene glycol, Group III received Livolin Forte®, Group IV received Lead acetate, Group V received LF® followed by lead acetate (pretreatment), and Group VI received lead acetate followed by LF (post-treatment). The regimen was given orally once a day for seven weeks. Blood sample was collected for the evaluation of haematological parameters at the end of the dosing period.
Results: Significantly (P≤0.05) lowered packed cell volume, red blood cell count, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration; of the lead acetate exposed rats, the pretreatment and the post-treatment groups respectively.
Conclusion: LF had no pretreatment and post-treatment effects on sub chronic lead acetate induced alterations in haematological parameters in adult male Wistar rats.

Key words: Livolin forte, lead acetate, toxicity, blood, sub-chronic