Assessment of Wound Healing Properties of Mangifera indica (Mango) Methanol Leaf Extract in Wistar Albino Rats

Sulaimon Olayiwola Folami; Ismail Adetayo Lawal; Fatai Olalekan Salaudeen; Muinat Yetunde Sebioniga-Lawal

doi:10.5455/JELM.20240703021534

Abstract
Abstract
Introduction: Medicinal plants have played a crucial role in healthcare systems throughout human history, dating back to ancient civilizations where natural remedies were the primary sources of medicine. Mangifera indica, commonly known as mango, has a long-standing legacy in traditional medicine,
Aim: To evaluate the wound healing potential of Mangifera indica methanol leaf extract (MIMLE) in Wistar albino rats.
Method: Standard protocols were employed for both qualitative and quantitative analyses of MIMLE. Excision wound models were used to determine the wound healing activity of Mangifera indica. Wounds were treated with ointment formulation of the extract (10% and 50% w/w) and Neobacin cream for 15days.
Results: Phytochemical screening of M. indica methanol leaf extract (MIMLE) revealed the presence of flavonoids, phenols, tannins, saponins, and alkaloids. Quantitative analysis determined the concentrations of these compounds, with flavonoids being the most concentrated (4.54 ± 0.047%), followed by phenols (3.47 ± 0.034%) and tannins (2.54 ± 0.157%). However, M. indica methanol leaf extract (MIMLE) result showed no significant difference (P<0.05) in wound length compared to the control group from day 0 to day 12, but a significant (P<0.05) healing effect on Day 15 in both the extract-treated and standard drug-treated groups compared to the untreated group
Conclusion: These results demonstrate that the Mangifera indica possesses healing properties, thereby supporting its traditional medicinal use in treating wounds.
Keywords: Mangifera indica, Methanol, Healing Properties, Wound excision and Alternative medicine.

Key words: Keywords: Mangifera indica, Methanol, Healing Properties, Wound excision and Alternative medicine.