Relationship between Lymphocyte to Monocyte Ratio and Contrast-Induced Nephropathy in Acute Coronary Syndrome patients treated with Percutaneous Coronary Intervention

Deniz Elcik; Mikail Yarlioglu; Fatih Oksuz; Mustafa Duran; Mehmet Tugrul Inanc

doi:10.5455/JMRR.20240621072959

Abstract
Aim: This study aimed to evaluate lymphocyte to monocyte ratio (LMR) for risk of CIN in patients with ACS undergoing PCI.
Methods: A total of 1001 ACS patients between 2017 and 2021 were included in the study. CIN was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥ 25% above baseline within 72 hours after the procedure. Patients were divided into two groups: patients with and without CIN. Demographics, clinical risk factors, angiographic and laboratory parameters, CIN incidence, and other in hospital clinical outcomes were compared between two groups.
Results: LMR at baseline was significantly lower in patients who developed CIN compared to those who did not (2.1±0.9 and 3.9±1.7, respectively; P < 0.001). In receiver operating characteristic analysis showed that at a cutoff of ≤3, the value of LMR exhibited 80.17 % sensitivity and 70.96% specificity for detecting CIN. At multivariate analyses, LMR ≤3 value (OR 5.525, 95% CI 2.518-12.123; P < 0.001) was one of significant independent predictors of CIN.
Conclusion: Our study suggested that LMR level on admission was independently associated with the development of CIN after PCI in patients with ACS.

Key words: ACS, CIN, lymphocyte to monocyte ratio