Streamlined Synthesis of Clopidogrel Utilizing Magnetically Recyclable Fe3O4 Nanoparticles through the Strecker Reaction

Siva Prasad Aviraboina; Harshita Gaddipati

doi:10.5455/JPPR.20231012104209

Abstract
Aim: The study explores the use of magnetite nanoparticles for eco-friendly α-aminonitrile synthesis via the Strecker reaction, aiming to provide a more efficient, cost-effective, and sustainable method.
Methods: The research involves an extensive exploration of magnetite nanoparticles, belonging to the inverse spinel group, as catalysts for the Strecker reaction. The magnetic properties of Fe3O4 nanoparticles facilitate their easy removal from reaction masses using an external magnet, eliminating the need for conventional filtration or centrifugation methods. Trimethylsilyl cyanide (TMSCN) is utilized as a cyanide ion source, known for its efficiency and user-friendly characteristics, aiming to enhance the eco-friendliness of the synthesis.
Results: Magnetite nanoparticles with FCC oxygen arrangement and Fe2+ and Fe3+ ions show potential applications in medical and organometallic chemistry. High saturation magnetization, low toxicity, and biocompatibility make them promising for drug delivery and MRI contrast agents.
Conclusion: The research presents an environmentally friendly Strecker reaction method using Fe3O4 nanoparticles, offering a promising alternative to traditional methods for α-aminonitrile synthesis and demonstrating the potential of magnetite nanoparticles.

Key words: magnetic, nanoparticles, immobilization, biocompatibility, clopidogrel, cardiovascular