Abstract
Background: Cefuroxime Axetil is a poorly water-soluble antibiotic with limited oral bioavailability. Enhancing its solubility is essential for improving therapeutic efficacy. This study explores the use of sodium lauryl sulfate (SLS) as a solubility enhancer in the tablet formulation of Cefuroxime Axetil. The object of current investigation is design, development, and evaluation of Cefuroxime Axetil (CA) tablet. Methods: Firstly, the solubility of a drug is poor it can lead to suboptimal bioavailability along with therapeutic efficiency. That’s why we were magnify the solubility of CA by using different concentration of the SLS and formulate the 250 mg tablet by using direct compression method takes trial batches. As a consequence, done post evaluation parameter and dissolved the tablet. After that in UV spectroscopy the maximum solubility was find. Completing the trial batches of the different concentration of SLS can be give desired result that menace enhance solubility of the drug. Result: During the experiment, 1% SLS shown maximum solubility in F1, F2, F3 batches along with better friability. However, F4 and F5 batches of CA were fail during friability test. Conclusion: At the end of experiment, we conclude that F3 batch shows good result with 98% drug release within 60 minutes. It directly indicates enhancement in solubility which leads to better therapeutic effect in the body.

Key words: Cefuroxime Axetil, Solubility enhance, SLS, Direct Compression, BCS Class II, Dissolution.