Experimental study on potential protective effect of camel milk on cholesterol-induced fatty liver disease of Albino Rats

Ayman Balla Mustafa; Abdalla Ramadan Elgenaidi; Emhemed Abukhattala

doi:10.5455/JELM.20240611115910

Abstract
Background: Fatty liver disease is considered to be the most common cause of persistently elevated liver enzymes in the general population and is significantly associated with higher body mass index and metabolic syndrome. Aim: The study was designed to investigate the therapeutic effect of camel milk on fatty diet-induced dyslipidemia and liver dysfunction in albino rats. Methods: 32 Wister Albino rats of both sexes with an average weight of 151.16±11.68 gm were divided into 4 groups. Group I (control group): The rats received standard ration. Group II: rats received a high-fat diet (HFD). Group III: free access to fresh milk plus a standard ration and group IV: rats were free access to fresh milk plus high fat diet. By end of experiment, 32 blood samples were collected and delivered promptly to the laboratory for biochemical examination. Numerical data were analyzed to determine the difference between means. Results: The result revealed that the mean of FBG, blood lipid, and liver enzymes were significantly different (P<0.05) between experimental groups. It showed the mean values of TC and TG were significantly (P<0.05) decreased in groups III and IV while it was increased in group II. Whereas mean values of ALT and AST showed a significant (P<0.05) increase in group II and decreased in groups III and IV. Conclusion: According to the observed favorable therapeutic effects of camel's milk on non-alcoholic fatty liver disease and dyslipidemia. The consumption of camel milk may be considered a nutraceutical and health booster in NAFLD patients and related circumstances.

Key words: Albino Rats, Camel Milk, High Fat Diet, Liver disease, Therapeutic Effect.