Nephroprotective Effects of Dayak Onion (Eleutherine palmifolia) Extract on BUN and Creatinine Serum Level in Mice (Mus musculus) Following Chronic Dose Administration of Monosodium Glutamate

Aldin Akbar Rahmatullah

doi:10.5455/JELM.20240705102300

Abstract
This research investigated the nephroprotective effects of Dayak onion (Eleutherine palmifolia) extract on mice subjected to chronic monosodium glutamate (MSG) exposure. The study utilized 25 male mice, approximately 11 weeks old and weighing 20 grams each, divided into five treatment groups. The control group (C-) received only 0.5% CMC-NA orally, while the positive control group (C+) was administered MSG at 4 mg/g body weight. Three experimental groups (T1, T2 and T3) received the same MSG dose plus varying concentrations of Dayak onion extract: 30, 60, and 120 mg/kg body weight, respectively. Following a 52-day treatment period, blood samples were collected via intracardiac puncture on day 53 after dislocation os cervical euthanasia. These samples were analyzed for Blood Urea Nitrogen (BUN) and serum creatinine levels. Analysis revealed significant differences in BUN and serum creatinine levels between the positive control group and all treatment groups. Notably, a dose-dependent decrease in these parameters was observed in the groups receiving Dayak onion extract, with levels declining as extract dosage increased. This trend suggests that the extract mitigated the detrimental effects of MSG on renal function. The study concluded that Dayak onion extract exhibited protective effects against MSG-induced kidney damage in mice, with the optimal dose identified as 120 mg/kg body weight. These findings offer valuable insights into the potential use of Dayak onion extract as a natural therapeutic agent for MSG-related kidney damage, paving the way for further research in this field.

Key words: BUN, Creatinin, Dayak Onion Extract, Monosodium glutamate, Nephroprotector