To Investigate the Effectiveness of Systemic Tropisetron Use and Intra-Abdominal Adhesion Barrier in Preventing Postoperative Pelvic Adhesions in a Rat Model

Ramazan Bayirli; Sinan Ozalp

doi:10.5455/JPPR.20240911120841

Abstract
Aim: Postoperative pelvic adhesions remain a significant challenge in gynecological and general surgeries, leading to considerable morbidity, including chronic pelvic pain, infertility, and bowel obstruction. Preventing the formation of postoperative adhesions is paramount in reducing associated morbidity. The aim of this study is to investigate preventive measures and advanced treatment interventions for postoperative pelvic adhesions.
Methods: In this study, 40 female Albino Wistar rats, each weighing between 200-250 grams and aged three months, were utilized. Three experimental groups and one control group were formed, each consisting of 10 rats. Intraperitoneal administration of 10 mg/kg xylazine and 50 mg/kg ketamine hydrochloride was used as the anesthesia method for all rats. After a five-day treatment period, the adhesions observed in the abdomen were examined microscopically and scored. The hydroxyproline levels after the five-day treatment period were examined in the groups.
Results: Adhesions were scored in the groups. The results of the intergroup comparisons related to the scoring. Accordingly, the highest score was observed in the control group, while the lowest score was detected in the Interceed group. Based on the histological scoring results, it was determined that scores of 3 and 4 were less frequent, while a score of 0 was more frequent in the amnion membrane and Interceed groups. Hydroxyproline levels were lower in the amnion membrane and Interceed groups, while they were higher in the control and tropisetron groups.
Conclusion: While significant progress has been made in preventing postoperative pelvic adhesions, challenges remain in translating these advances into consistent clinical outcomes.

Key words: Postoperative Pelvic Adhesions Surgical Trauma, Chronic Pelvic Pain, Hydroxyproline Levels.