PHARMACOLOGICAL INVESTIGATION OF ANCHOMANES DIFFORMIS FOR ITS ANTIANAEMIC ACTIVITIES.

Mojisola Ayodele-Asowata; Abdul Onoruoiza Momoh; Folusho Olomiyete; Babawale Peter Olatunji; Felix Afolabi; Oghale Godwin

doi:10.5455/JRCM.20240603100510

Abstract
ABSTRACTS:
Aim: Easy access to functional food may reduce the menace and help to reduce mortality rate due to malnutrition, hence, the reason for this research. This is because Anchomanes difformis is one vegetable that can be easily found in the wild. The anti-anaemic properties of the plant was investigated coupled with its proximate, mineral and phytochemicals contents.
Methods: Thirty–six female wistar rats were selected for in-vivo anaemia evaluation. They were induced with cyclophosphamide for a period of five days, in order to induced bleeding into them before commencement of treatment with 200mg/kg and 300mg/kg of Anchomanes difformis methanolic leaf extracts for twelve days.
Results: The results shows that the extracts compete favorably with the group that was treated with Cobalamin and the plant contains high mineral composition with sodium being the highest with 150. 30 ± 0.10 ppm. Other minerals very high in the extract are potassium (412.40 ± 1.10 ppm), Calcium (295 ppm), and Phosphorous (71 ppm) which are essential for pregnant women, In addition, Anchomanes difformis was rich in carbohydrate. The following phytochemicals were at peak in the GCMS analysis- hexadecanoic acid, ethyl ester, Indole, Hexanamide and Adonite.
Conclusion: The methanol leaf extracts of Anchomanes difformis possess anti-anaemic properties due to its ability to reverse all the negative effects caused by cyclophosphamide and it is recommended for pregnant women and anaemic children.

Key words: Anchomanes difformis; Anaemia; Effects; Pharmacology; Minerals.